<p>The Buffalo Bills (7-2) bring a three-game winning streak into a matchup against the Arizona Cardinals (5-3) on Sunday, November 15, 2020 at State Farm Stadium. Arizona is just a 2.5-point favorite in the game. The over/under is set at 56.0 for the contest.</p>
<h4>How To Watch</h4>
<p><strong>Time:</strong> 4:05 PM EST<br /><strong>TV Channel:</strong> CBS</p>
<h4>Betting Information</h4>
<table class="table">
<caption>Cardinals vs Bills Betting Information</caption>
<thead>
<tr>
<th scope="col">Favorite</th>
<th scope="col">Spread</th>
<th scope="col">Favorite Spread Odds</th>
<th scope="col">Underdog Spread Odds</th>
<th scope="col">Total</th>
<th scope="col">Over Total Odds</th>
<th scope="col">Under Total Odds</th>
<th scope="col">Favorite Moneyline</th>
<th scope="col">Underdog Moneyline</th>
</tr>
</thead>
<tbody>
<tr>
<td>Cardinals</td>
<td>-2.5</td>
<td>-115</td>
<td>-105</td>
<td>56.0</td>
<td>-110</td>
<td>-110</td>
<td>-145</td>
<td>125</td>
</tr>
</tbody>
</table>
<h4>Cardinals vs Bills: Last 5 Meetings</h4>
<p>Buffalo has an edge against Arizona over the last five meetings between these two squads, collecting a 4-1 record in those games. Buffalo outscored Arizona 138-110 in those five head-to-head matchups.</p>
<table class="table">
<caption>Cardinals vs Bills: Last Five Meetings</caption>
<thead>
<tr>
<th>Date</th>
<th scope="col">Home Team</th>
<th scope="col">Total Yards</th>
<th scope="col">Result</th>
</tr>
</thead>
<tbody>
<tr>
<th scope="row">9/25/2016</th>
<td>Bills</td>
<td>348-297 ARI</td>
<td>33-18 BUF</td>
</tr>
<tr>
<th scope="row">10/14/2012</th>
<td>Cardinals</td>
<td>332-306 ARI</td>
<td>19-16 BUF</td>
</tr>
<tr>
<th scope="row">10/5/2008</th>
<td>Cardinals</td>
<td>-</td>
<td>41-17 ARI</td>
</tr>
<tr>
<th scope="row">10/31/2004</th>
<td>Bills</td>
<td>-</td>
<td>38-14 BUF</td>
</tr>
<tr>
<th scope="row">12/19/1999</th>
<td>Cardinals</td>
<td>-</td>
<td>31-21 BUF</td>
</tr>
</tbody>
</table>
<h4>Betting Insights: Last Three Games (Both Teams)</h4>
<ul>
<li>Arizona has gone 2-1 against the spread and 2-1 overall in their last three outcomes.</li>
<li>The over has been familiar to Arizona. They have gone over the total three times in their last three contests.</li>
<li>The Cardinals and their opponents have combined to score an average of 61.3 points in their last three games, 5.3 more than the 56.0 over/under in this matchup.</li>
<li>Buffalo is just 1-2 against the spread and 3-0 straight up in their last three outcomes.</li>
<li>Buffalo has gone over the total two times in their last three games.</li>
<li>The Bills have averaged a total of 50.3 combined points in their last three games, 5.7 fewer than this game's over/under of 56.0.</li>
</ul>
<h4>Total Facts</h4>
<ul>
<li>The Cardinals have an average total of 51.8 in their outings this year, 4.2 fewer points than this game's over/under.</li>
<li>Bills outings this season have a 52.8-point average over/under, 3.2 fewer points than this game's point total.</li>
<li>Arizona's games have gone over 56.0 points two times this season 25% of matchups).</li>
<li>Four of Buffalo's games have gone over 56.0 points this year (44.4% of matchups).</li>
<li>These two teams average a combined 56.1 points per game, 0.1 more points than this matchup's over/under.</li>
<li>Opponents of these teams combine to average 48.4 points per game, 7.6 fewer points than this matchup's total.</li>
</ul>
<h4>Cardinals Betting Insights</h4>
<ul>
<li>Arizona is an even 2-2 against the spread in home games this year, and is 2-2 overall at home.</li>
<li>Arizona has compiled a 5-3 record against the spread this season.</li>
<li>Most of Arizona's games this year -- eight out of eight -- have gone over the point total (100%).</li>
<li>The Cardinals have turned the ball over 1.2 times per game this season, while the Bills have averaged 1.6 takeaways per contest.</li>
<li>In games where they turn the football over 1.2 times or fewer this season, Arizona is 4-2 overall and 4-2 against the spread.</li>
<li>Buffalo is 4-1 against the spread and 5-0 overall this season when they force at least 1.6 turnovers in a game.</li>
</ul>
<h4>Bills Betting Insights</h4>
<ul>
<li>Buffalo has a losing 4-5 record against the spread.</li>
<li>The Bills have a losing ATS record of 2-4 when playing as at least 2.5-point underdogs.</li>
<li>Buffalo's games have hit the over in seven out of nine outings this season (77.8%).</li>
<li>This season, the Cardinals have forced an average of 1.2 turnovers per game compared to the 1.2 times Bills have turned the football over in each contest.</li>
<li>When Buffalo turns the football over 1.2 times or fewer this season, they are 5-1 overall and 2-4 against the spread.</li>
<li>When they force more than 1.2 turnovers in a game this season, Arizona is 3-0 against the spread and 3-0 overall.</li>
<li>Buffalo's record against the spread in away games this year is just 1-3, and its record on the road overall is 3-1.</li>
</ul>
<h4>Injury Report</h4>
<p><strong>Cardinals:</strong></p>
<p>Leki Fotu: Out (Ankle), </p>
<p>Budda Baker: Questionable (Groin), </p>
<p>Kenyan Drake: Questionable (Ankle), </p>
<p>Justin Murray: Out (Hand), </p>
<p>Jordan Phillips: Out (Hamstring), </p>
<p>Maxx Williams: Questionable (Ankle), </p>
<p>Deionte Thompson: Questionable (Knee), </p>
<p>Dre Kirkpatrick: Questionable (Thigh)
</p>
<p><strong>Bills:</strong></p>
<p>Micah Hyde: Questionable (Ankle), </p>
<p>Cody Ford: Questionable (Ankle), </p>
<p>Taiwan Jones: Out (Hamstring), </p>
<p>Del'Shawn Phillips: Out (Quadricep)
</p>
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View NFL betting odds, lines, and player stats for the matchup between the Arizona Cardinals and the Buffalo Bills on Sunday, 11/15/2020.

Josh Allen and the Bills are only 2.5-point underdogs against the Cardinals.